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pentobarbital will lessen the extent or result of quetiapine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.Watch Carefully (one)pentobarbital will lower the level or effect of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Loss of, or diminished response to tofaciti